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KMID : 1036020200090020231
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지질.동맥경화학회지
2020 Volume.9 No. 2 p.231 ~ p.242
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Metabolic Reprogramming of Macrophages in Atherosclerosis: Is It All about Cholesterol?
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Yvan-Charvet Laurent
Ivanov Stoyan
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Abstract
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Hypercholesterolemia contributes to the chronic inflammatory response during the progression of atherosclerosis, in part by favoring cholesterol loading in macrophages and other immune cells. However, macrophages encounter a substantial amount of other lipids and nutrients after ingesting atherogenic lipoprotein particles or clearing apoptotic cells, increasing their metabolic load and impacting their behavior during atherosclerosis plaque progression. This review examines whether and how fatty acids and glucose shape the cellular metabolic reprogramming of macrophages in atherosclerosis to modulate the onset phase of inflammation and the later resolution stage, in which the balance is tipped toward tissue repair.
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KEYWORD
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Hematology, Metabolism, Atherosclerosis, Macrophage, Cholesterol
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